Link2Trials Q&A_25

• Lack of awareness– Many patients are unaware of trial opportunities.
• Strict eligibility criteria – Complex inclusion/exclusion criteria limit participation.
• Fear of side effects – Concerns about safety and unknown risks discourage participation.
• Inconvenient trial locations – Long travel distances deter patients.
• Time commitment– Frequent visits and long follow-ups are burdensome.
• Mistrust in research – Historical issues have led to skepticism, especially in certain communities.

Addressing these barriers through better outreach, flexible trial design, and patient centric approaches can significantly improve enrollment rates.